There has been a second break-in in the space of a few weeks at Dougie Mac's warehouse in Burslem.
Thousands of pounds worth of damage was caused after criminals broke into the warehouse during the early hours of Sunday morning.
In this latest incident, cash and jewellery was taken from a safe they destroyed.
It follows a spate a of burglaries in its Meir shop and Burslem warehouse at the start of the month.
Police are investigating the case and a forensics team have swept the building for evidence to bring the culprits to trial.
Dougie Mac’s Head of Retail, Liz Clarke said: "It’s incredibly unfortunate that yet again, we’ve experienced the heartlessness of those who choose to steal from a local charity that strives to provide care to local families when they need it most.
“Our security measures have been tightened across the business to pre-empt the actions of such criminals and therefore monies stored on-site is at an absolute minimum so we are at least thankful that it is only mainly damage we now have to deal with. However, the damage to property is substantial and we call on the generosity of the local people to consider making a donation to help us fund repairs.
“We rely very heavily on our shops right across Stoke-on-Trent and North Staffordshire to help fund our vital care services for patients and families living with a life limiting condition. A quarter of our income is raised from our charity shop chain and without them, many of our care services would unfortunately not exist. As 80% of our running costs are funded by voluntary donations from the public, it is with great regret that when Dougie Mac is targeted by thieves, it is the generous local community who are sadly being stolen from.
“Despite this shameful event, we are pleased to report that our staff and volunteers have pulled together and have continued trading with no down-time whatsoever. The immoral actions of criminals will not dampen the spirit of our team and our supporters who strive to ensure Dougie Mac can continue to deliver exceptional care 24 hours a day, 365 days a year.”
Anyone who wishes to make a donation can do so here: https://www.dmhospice.org.uk/donate/